Enhancing bacterial survival through phenotypic heterogeneity
نویسندگان
چکیده
منابع مشابه
Phenotypic Heterogeneity in Bacterial Populations
Genetically uniform bacterial cells exhibit heterogeneity such as intrapopulation differences in metabolism as well as variation in growth rate. Additionally, phenotypic heterogeneity in more complex developmental processes where a portion of a population performs specialized functions has been described. Heterogeneity within populations of bacterial cells ensures that a small fraction of the p...
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Most bacteria live in colonies, where they often express different cell types. The ecological significance of these cell types and their evolutionary origin are often unknown. Here, we study the evolution of cell differentiation in the context of surface colonization. We particularly focus on the evolution of a 'sticky' cell type that is required for surface attachment, but is costly to express...
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With interest we read the article by Dvorakova et al. about 50 Czech patients carrying the m.3243ANG mutation [1]. It raises questions and concerns. Since MELAS is a progressive disease, we should be informed about the long-term follow-up findings in the 50 mutation carriers. How many of the 17 patients without clinical manifestations at inclusion developed MELAS during follow-up? How many of t...
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microRNAs are small noncoding RNAs that reduce protein output from complementary target mRNA transcripts. They are a conserved family of gene regulators in multicellular organisms, targeting much of the transcriptome. This pervasiveness is at odds with their generally modest repressive capacity, and suggests that microRNAs might not be cellular decision makers; rather they might ensure the stab...
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ژورنال
عنوان ژورنال: PLOS Pathogens
سال: 2020
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.1008439